キャピラリー電気泳動を用いる抱水クロラール並びにそのシロップ剤の安定性の検討

概要

論文の詳細を見る
Stabilities of chloral hydrate in an aqueous solution and its medicated syrup were examined by high performance capillary electrophoresis. Analysis of the concentration of chloral hydrate indicated that there was no obvious change in the concentration of chloral hydrate boty in the aqueous solution and in the syrup preparation after keeping them for 3 months at room temperature or at 60℃. The lowering of pH was more obvious in the syrup solution than in the aqueous solution, and this tendency was estimated to be due to the formation of hydrochloric acid. We propose that the stabilities of the preparation of chloralhydrate should be monitored by observing pH changes.
社団法人日本薬学会の論文
1999-05-01