もののかたちの創作と造作

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When matter assembles to take a shape, there arises a function specific to the shape, and at the same time the value is produced. A shape of matter originates from physics of the constituents combined with the environmental conditions holding the matter. It is convenient for recognition of shape to classify the matter in three categories ; non-living matter , living organic matter and manmade matter. In the case of non-living matter, a process of shape arrangement is clearly understood by means of thermodynamics. It is also distinctly recognized that, in total stabilizing energy of the shape ΔG°, the entropy term TΔS° is responsible for the shape creation. Shape arrangement often proceeds through kinetic regime, in such cases (ΔG°)〓 or T(ΔS°)〓 should be adopted. Synthetical formation of the shape can of course be attained thermodynamically or kinetically. In the case of living organic matter, the creation of the shape depends on evolution, which is undoubtedly based on environmental conditions as well as physical properties of the matter itself. A key compound in shape arrangement of living organic matter is a globular protein. For the formation of the shape of the globular protein, nature uses chaperone while human beings utilize a refolding technique known as an important down-stream art of the recombinant DNA process. Detailed description of the art appears in a text as the course to achieve the quantitative refolding of several globular proteins. The shape of man-made matter keeps the successive creation via evolution operated by the market economics. Formation of the shape is managed skillfully by means of mechanical engineering and/or material sciences. In the last section, some aspects on the possibility of a man-made enzyme are described.
社団法人日本薬学会の論文
1999-11-01

もののかたちの創作と造作

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