塩素処理による水中有機物の化学変化(第5報)ナフトールと次亜塩素酸との反応で生成するエーテル可溶成分の変異原性試験

概要

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Mutagenicity of ether-extracted fractions obtained by the reactions of naphthols and hypochlorite in dilute aqueous solutions was investigated by using Ames Salmonella typhimurium TA98 and TA100 strains. No mutagenic activity against TA98 and TA100 strains both with and without rat liver homogenates (S-9) was observed for the ether fractions obtained from α-and β-naphthols (NT) treated with chlorine at low HOCl/NT ratios, although these fractions were toxic toward the tester strains. The ether fraction obtained from β-naphthol treated with chlorine at high HOCl/NT ratios however, exhibited the mutagenicity against the strain TA100 without S-9 Mix. The compounds identified in the ether fractions : chloronaphthols, chloronaphthoquinones, and other carboxylic acids, did not exhibit the mutagenicity toward TA98 and TA100 strains in the presence and absence of mammalian metabolic activation. No chemicals which could be determined to be responsible for the mutagenicity of the reaction mixture was isolated ; it is, however, obvious that certain materials were produced by the reaction of β-naphthol and chlorine in dilute aqueous solutions.
公益社団法人日本薬学会の論文
1982-06-30