ピレスロイド系殺虫剤およびその共力剤(1, 1'-オキシビス[2, 3, 3, 3-テトラクロロプロパン])のAmes変異原性

概要

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Pyrethroid pesticides(tetramethrin, permethrin, empenthrin and allethrin), with 1, 1'-oxybis[2, 3, 3, 3-tetrachloropropane](S421)as a synergist, were assayed for their mutagenic activities in both TA98 and TA100 strains by the micro-suspension method. Pyrethroid pesticides tested(below 1mg per plate)in this assay were not mutagenic in either TA98 or TA100 strains, with or without S9 mix. Only the S421 compound was found to be mutagenic with 215 revertants per mg towards TA100, in the absence of S9 mix. The addition of S9 mix reduced mutagenic activity. Acetone extracts of household product samples were also assayed for their mutagenic activity in the TA100 strain without S9 mix. Pyrethroid pesticides and S421 compound concentrations were assayed by GC/MS. All extracts were mutagenic in the TA100 strain:their activities accounted for 9.3 to 74.4% by the S421 compound content of the extracts, depending on the product.
日本環境変異原学会の論文
1998-04-10