ポリクロロフェノキシフェノール(プレダイオキシン)及びそれらの水中光分解生成物の変異原性試験

概要

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Polychlorinated phenoxyphenols (PCPPs), including predioxins and isopredioxins, and their photo-degradation products in aqueous solution were tested for mutagenicity on Salmonella typhimurium TA98 and TA100 strains. Mutagenic effects of Irgasan DP 300 [5-chloro-2-(2,4-dichlorophenoxy) phenol] as a typical predioxin and PCPPs (chlorophenol dimers) could not be observed on both TA98 and TA100 strains with and without S9 mix, because of thier great toxicity to tester strains. No mutagenic effects were also observed for 2-alkylated PCPPs (chloro-2-alkylphenol dimers) on both tester strains. However, some 4-alkylated PCPPs (chloro-4-alkylphenol dimers) were mutagenic on TA100 strain without S9 mix, and great mutagenicity was detected for 4-methylated PCPPs. PCPPs in aqueous solution were found to be converted to compounds with mutagenicity to TA100 strain without S9 mix, when the solution was subjected to photo-irradiation in the presence of chlorine for 5 h. In addition, a mutagenic effect of 4-methylated PCPPs solution on TA100 strain without S9 mix was shown to be remained about 50% of the original activity, even after treatment with chlorine alone and photo-irradiation in the presence of chlorine for 5 h. However, no mutagenic effects of Irgasan DP300 in aqueous solution were observed after any treatments.
社団法人日本薬学会の論文
1995-06-30