フェノール化合物の塩素処理における変異原物質の生成挙動及びそれらの変異原物質生成能

概要

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Aqueous phenol solutions, as humic model compounds, were treated with chlorine under various experimental conditions. These chlorinated waters after dechlorination and diethyl ether extracts from the waters were tested for their mutagenic effects on TA98 and TA100 strains with and without S9 mix. The diethyl ether extracts were also tested for their product distributions. Aqueous chlorination under an acidic condition generated direct-acting mutagens on TA100 strain from non-mutagenic compounds. These mutagens formed from phenol and its chlorinated derivatives were shown to be both polar and non-polar compounds, while, these produced from cresols, di- and trihydric phenols were polar ones. Higher mutagenic potential formation during aqueous chlorination were observed for simple phenol and p-cresol. The parent compounds were shown to produce a variety of chlorination products, including chlorine-substituted, oxygenated, and hydroxylated compounds. The formation of chlorination products and mutagenic substances was dependent on the reaction pH and chlorine dose. The significance of these findings for water chlorination systems is discussed.
公益社団法人日本薬学会の論文
1998-08-31