Geotrichum candidumの^<14>C-Leucine取込みに対する殺菌剤の阻害

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The efficacy and the mode of action of fungicides were examined by the growth of Geotrichum candidum and by the incorporation of ^<14>C-leucine by the fungus into the whole cell and into the protoplast. According to the fungal growth measured by turbidimetry, the most effective inhibitor was an organomercury compound. The inhibition of fungal growth was also observed with organotin compound and quaternary ammonium chloride. Organotin compound most strongly inhibited the incorporation of ^<14>C-leucine into the whole cell. No remarkable relationship was observed between the inhibition rate of fungal growth and that of the incorporation of ^<14>C-leucine. The experiment on the incorporation of ^<14>C-leucine into the whole cell and into the protoplast indicated that organotin compound and organosulfur compound of carbamate type strongly inhibited the incorporation of ^<14>C-leucine in the presence of a cell wall. As the organomercury compound, quaternary ammonium chloride, and chlorine water showed a strong affinity to G. candidum, these agents should be used for shock dosage, while organotin and organosulfur compounds seemed to be suitable for use as a continuous dosage.
公益社団法人日本薬学会の論文
1976-04-30