The Concentrations of the Bound Metals in Hepatic Metallothionein of Rats injected with Cadmium

概要

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The relationship between the amount of injected Cd and the bound metal concentrations of rat hepatic metallothionein (MT) was investigated. Rats were injected subcutaneously with 0.1,0.3,0.6 or 1.2 mg Cd (single injection) or 0.1 mg Cd 3,6 or 12 times on successive days (plural injection). When the MT induced by single injection was compared with that induced by plural injection, there was no difference in the total concentration of three bound metals (Cd, Cu and Zn) though there were small differences in the concentration of each metal in the MT injection of the same amount of Cd. The total bound metal concentration increased and each metal content ratio changed depending on the total amount of injected Cd. Due to turnover, the content ratios of Cd and Zn in the MT became lower and higher than those in the initial induced MT, respectively, and the total bound metal concentration decreased.
社団法人日本薬学会の論文
1982-02-28