Effectiveness of the Elcatonin Transdermal System for the Treatment of Osteoporosis and the Effect of the Combination of Elcatonin and Active Vitamin D_3 in Rat

概要

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The efficacy of percutaneous elcatonin (EC), a hypocalcemic peptide, in the treatment of experimental osteoporosis in rats was evaluated in vivo. Additionally, the effect of the combined use of EC and active vitamin D_3 (1,25(OH)_2D_3) for the treatment was compared with those of three other groups : 1,25(OH)_2D_3 alone, estradiol plus 1,25(OH)_2D_3,and a placebo, and low calcium diet (low Ca). The EC transdermal system and the EC plus 1,25(OH)_2D_3 system, applied to the rat abdominal skin 6 times for 48 h, significantly increased the ash weight and calcium content of the tibia in the rats, compared with those of placebo group (p<0.05). The EC systems also slightly lowered the alkaline phosphatase activity in plasma of the morbid rats, without a difference in the plasma calcium content. These EC systems were superior to the 1,25(OH)_2D_3 system and the estradiol plus 1,25(OH)_2D_3 system in improving osteoporotic parameters. Thus, the EC systems were concluded to be an efficient drug delivery system for Paget's disease and osteoporosis.
社団法人日本薬学会の論文
1993-09-15