Effects of Neurotropin on Rat Liver Microsomes and Lysosomes, and in Vitro Lipid Peroxidation

概要

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The effects of Neurotropin (NSP) on lysosomal and microsomal enzyme activities, antioxidant levels and fatty acid composition of microsomal phospholipids in rat liver were studied before and after CCl_4 intoxication. The effect on in vitro lipid peroxidation was also determined. NSP posttreatment (60 mg/kg/d for 3 and 7 d after CCl_4) did not produce a significant recovery of the enzyme activities, while NSP pretreatment (60 mg/kg/d for 7 d before CCl_4) partly prevented the decrease in lysosomal enzyme activities after CCl_4 intoxication and increased the level of water-soluble antioxidants as compared with that of CCl_4-treated rats. NSP significantly decreased ascorbateinduced lipid peroxidation in vitro, by 20% at the concentration of 1 mg/ml, without affecting the reduced nicotinamide adenine dinucleotide phosphate (NADPH)-induced lipid peroxidation. Further, NSP significantly enhanced, by 20-23%, the protecting effect of inhibitors (CoCl_2 and aniline) of lipid peroxidation. Thus, NSP pretreatment appears to have a partial protecting effect against CCl_4 intoxication and accompanying lipid peroxidation.
社団法人日本薬学会の論文
1985-02-25