Anti-inflammatory Activity of Ointments of Indomethacin and Its Calcium Salt Applied to Abdominal Skin of Rat

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Anti-inflammatory activities of ointments containing indomethacin (IND) and its calcium salt (IND-Ca), applied to abdominal skin, were investigated in rats with carrageenin-induced paw edema and adjuvant arthritis, in addition to estimation of the irritant effect of the formulations on rabbit skin. The IND and IND-Ca gel ointments (1%, 0.14 g, 1 cm^2)applied to skin produced potent inhibitory effects on the paw edema and adjuvant arthritis, nearly equal to that after oral dosing (2.5 and 5.0 mg/kg) of IND. The 0.5% drug ointments also exerted a marked inhibitory effect on carrageenin-induced paw edema. These ointments produced only slighy irritation on rabbit skin. The irritancy of IND-Ca dissolved in diethylene glycol monoethyl ether was almost negliegible, while IND solution prevented hair growth at the application sites for several days. The results suggest that IND-Ca ointment is suitable for clinlcal application.
社団法人日本薬学会の論文
1988-02-25