インドメタシンのヘアレスラット皮膚透過に対する呉茱萸の促進作用

概要

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We have reported that the antinociceptive and anti-inflammatory effects of indomethacin (IND) ointments with 50% ethanol extract (G-ext) from Evodiae Frutus (dried fruits of Evodia rutaecarpa var. bodinieri) are enhanced compared with IND ointment without Gext. In this study, the effect of G-ext on enhancing the skin permeation of IND was investigated by using hairless rats in vitro and in vivo. The concomitant treatment with G-ext (3% in ointment) clearly enhanced the flux of IND 2-fold, but none of its three major components (limonin, evodiamine and rutaecarpine) died. Thus, the in vitro enhancing effect ofG-ext on transdermal penetration of IND may be ascribed to another component(s) of G-ext. The in vivo application of the IND ointment with 3% G-ext produced higher plasma IND concentrations, but lowered the remaining amounts of IND in skin, compared with those of the.IND alone. These results suggest that the IND ointment with 3% G-ext is useful as antinociceptive and anti-inflammatory formulation due to the pharmacological effect of G-ext itself and the lowering effect of G-ext on the stratum corneum barrier consequently increases in plasma concentration of IND.
2003-12-20