Inhibitory Effect of Murine Kidney Extracts on the Proliferation of Murine Mast Cells
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概要
- 論文の詳細を見る
We examined the effect of murine kidney extract (MKE) on the clonal growth of mast cells from murine peritoneal cells. Adding MKE resulted in a 40% inhibition of colony formation of mast cells in a methylcellulose culture, and a 90% decrease in mast cell numbers and histamine content in mast cells in a liquid culture containing stem cell factor and interleukin-3. The mast cell inhibitory factors in MKE were heat sensitive proteins of approximately 560 and 24 kDa. These results suggest that MKE contains regulators that suppress the growth of murine mast cells and histamine synthesis.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
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KASHIWAKURA Ikuo
Laboratory of Radiological Technology, Hirosaki University School of Health Sciences
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Kashiwakura Ikuo
Dep. Of Radiological Life Sciences Hirosaki Univ. Graduate School Of Health Sciences
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TAKAGI Yoshinari
Lab. Radiopharm. Sci., Hokkaido Coll. Pharm.
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MURAKAMI Miho
Laboratory of Radiopharmaceutical Sciences, Hokkaido College of Pharmacy
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HAYASE Yukitoshi
Laboratory of Radiopharmaceutical Sciences, Hokkaido College of Pharmacy
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TAKAGI Yoshinari
Laboratory of Radiopharmaceutical Sciences, Hokkaido College of Pharmacy
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Murakami Miho
Lab. Radiopharm. Sci. Hokkaido Coll. Pharm.
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Hayase Y
Laboratory Of Radiopharmaceutical Sciences Hokkaido College Of Pharmacy
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Takagi Yoshinari
Lab. Radiopharm. Sci. Hokkaido Coll. Pharm.
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Kashiwakura Ikuo
Graduate School Of Health Sciences Hirosaki University
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Kashiwakura Ikuo
北海道薬科大学 放射薬品
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