PRODUCTION OF METALLOPROTEINASE IN GASTRIC TISSUE WITH ACETIC ACID-INDUCED ULCER OR TAUROCHOLIC ACIDINDUCED GASTRITIS
スポンサーリンク
概要
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A metalloproteinase was extracted from a medium of cultured gastric tissues following acetic acid-induced ulcer or taurocholic acid-induced gastritis, and the enzyme was partially purified by Sephadex G-200 column chromatography. This proteinase was released in active and latent forms with apparent molecular weights of 170000 and 210000,respectively. Its activity was abolished by treatment with ethylenediaminetetraacetic acid or 1,10-phenanthroline, but not with phenylmethylsulfonyl fluoride or soybean trypsin inhibitor. This enzyme degraded type I gelatin and type IV collagen but did not attack type I collagen. In contrast, very little of this enzyme was released from gastric tissue following erosion caused by water-immersion stress or from normal gastric tissue. These results suggest that this metalloproteinase plays an important role in gastric lesions by breaking down the basement membrane.
- 公益社団法人日本薬学会の論文
著者
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MORI YO
Department of Biochemistry, Tokyo College of Pharmacy
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MURAKAMI Shigeru
Department of Breast Oncology, National Hospital Kyushu Cancer Center
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Nakanishi J
Department Of Biochemistry Tokyo College Of Pharmacy
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NAKANISHI JOTARO
Department of Biochemistry, Tokyo College of Pharmacy
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ISHIKURA YOSHIHARU
Department of Biochemistry, Tokyo College of Pharmacy
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TSUCHIYA SATOKO
Department of Biochemistry, Tokyo College of Pharmacy
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Mori Yo
Department Of Biochemistry Tokyo College Of Pharmacy
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Tsuchiya S
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Murakami S
Taisho Pharmaceutical Co. Ltd. Saitama Jpn
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Murakami Shigeru
Department Breast Surgery Hiroshima University Hospital
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Ishikura Yoshiharu
Department Of Biochemistry Tokyo College Of Pharmacy
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Tsuchiya Satoko
Department Of Biochemistry Tokyo College Of Pharmacy
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