THE STUDIES ON THE ROLE OF GASTRIC GLYCOPROTEINS WITH REFERENCE TO CYTOPROTECTION : PROTECTIVE EFFECT OF PROSTAGLANDIN E_2 AND SOFALCONE ON ETHANOL-INDUCED NECROSIS

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概要

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• The gastric cytoprotective action of prostaglandin E_2 (PGE_2) and sofalcone was studied in rats. The in vitro incorporating activity of ^3H-glucosamine into the gastric macromolecular glycoproteins was examined when PGE_2 (0.1 mg/kg, p.o.) or sofalcone (100 mg/kg, i.p.) was administered 5,15 or 30 min before the oral administration of absolute ethanol. The cytoprotective effect of PGE_2 against gastric mucosal damage was demonstrated 5 min after PGE_2 was given orally. The cytoprotective effect by sofalcone was seen after 15 min. However, during this period, the decrease in gastric macromolecular glycoprotein synthesis induced by the ethanol damage could not be restored by pretreatment with PGE_2 or sofalcone. On the other hand, the reduction in the content of the gastric macromolecular glycoproteins by the ethanol damage was found to be prevented to a significant extent by pretreatment with PGE_2. The same phenomenon was also observed in the administration of sofalcone. Accordingly, PGE_2 has stimulating effect on the gastric glycoproteins biosynthesis, but this effect can not be considered as the mechanism responsible for cytoprotection, if indeed a single mechanism exists. Thus, it is suggested that the adhesion or maintenance of secreted macromolecular glycoproteins to the gastric tissue is closely related to cytoprotection.

• 公益社団法人日本薬学会の論文

著者

• Fujimoto Noboru

  Department Of Biochemistry Tokyo College Of Pharmacy

• Mori Y

  Department Of Biochemistry Tokyo College Of Pharmacy

• Suwa T

  大正製薬(株)開発研究所薬物動態研究室

• Suwa Toshio

  Dept.of Biochemistry Tokyo College Of Pharmacy:(present Address) Research Center Taisho Pharmaceutic

• FUJIMOTO NOBORU

  Dept.of Biochemistry, Tokyo College of Pharmacy

• MURAKAMI SHIGERU

  Dept.of Biochemistry, Tokyo College of Pharmacy

• MORI YO

  Dept.of Biochemistry, Tokyo College of Pharmacy

• Murakami S

  Taisho Pharmaceutical Co. Ltd. Saitama Jpn

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