Effect of an anti-ulcer agent, 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy) chalcone (SU-88), on the biosynthesis of gastric sulfated mucosubstances in restrained and water-immersed rats.
スポンサーリンク
概要
- 論文の詳細を見る
2'-Carboxymethoxy-4, 4'-bis(3-methyl-2-butenyloxy) chalcone (SU-88) has an anti-ulcer effect which is considered to increase the resistant factors of the gastric mucosa. In order to clarify the mechanism of the action of SU-88, the biosynthesis of gastric sulfated mucosubstances (SMS) in vivo and in vitro was investigated in rats with gastric erosion induced by restraint and water-immersion. The incorporation of <SUP>35</SUP>S-sulfate into gastric SMS was significantly reduced 18 hr after the onset of stress. Pretreatment with SU-88 (500 mg/kg, p.o., x10 days) prevented a reduction in the incorporation of <SUP>35</SUP>S-sulfate due to stress when <SUP>35</SUP>S-sulfate was administered in vivo. On the contrary, the incorporating activity of <SUP>35</SUP>S-sulfate into the SMS in the isolated rat gastric mucosa with erosion was significantly increased 12 hr after the onset of stress, as compared with that of the control group in vitro. The incorporation of <SUP>35</SUP>S-sulfate into the SMS was still further increased by the oral administration of SU-88. The mode of action of SU-88 on the biosynthesis of SMS was discussed.
- 公益社団法人 日本薬理学会の論文
著者
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Mori Yo
Department Of Biochemistry Tokyo College Of Pharmacy
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Suwa Toshio
Research Center Taisho Pharmaceutical Co. Ltd.
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Fukushima Kiyomi
Research Center Taisho Pharmaceutical Co. Ltd.
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Kyogoku Kazuaki
Research Center Taisho Pharmaceutical Co. Ltd.
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KYOGOKU Kazuaki
Research Center, Taisho Pharmaceutical Co., Ltd.
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EDO Hiroharu
Department of Biochemistry, Tokyo College of Pharmacy
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