ACTIVATION OF MITOMYCIN C AND QUINONE DRUG METABOLISM BY NADPH-CYTOCHROME P-450 REDUCTASE
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概要
- 論文の詳細を見る
Microsomal NADPH-cytochrome P-450 reductase (EC 1.6.2.4) and xanthine oxidase (EC 1.2.3.2) catalyzed the activation of antitumor antibiotic, mitomycin C, under anaerobic conditions. Under aerobic conditions, NADPH-cytochrome P-450 reductase catalyzed the quinone structure containing antitumor compound-dependent NADPH oxidation. With our previous results, the direct contribution of NADPH-cytochrome P-450 reductase to the quinone drug metabolism was generalized.
- 公益社団法人日本薬学会の論文
著者
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Oki Toshikazu
Central Research Laboratories Sanraku-ocean Co. Ltd.
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Komiyama Tadazumi
Central Research Laboratories Sanraku-ocean Co. Ltd.
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INUI TAIJI
Central Research Laboratories, Sanraku-Ocean Co., Ltd.,
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Inui Taiji
Central Research Laboratories Sanraku-ocean Co. Ltd.
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