Mass Fragmentographic Determination of d- and l-Chlorpheniramine with Aid of the Stable Isotope Technique
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the pharmacokinetics of d-chlorpheniramine (d-CPA) and its l-isomer, d-CPA-d_6 and l-CPA-d_0 were administered orally and simultaneously to healthy adult volunteers. Both isomers in the serum were measured by chemical ionization-mass fragmentography using dl-CPA-d_<13> as an internal standard. The concentration of d-isomer was higher than that of l-isomer and the ratio (d/l) of both isomers was 1.9-3.1,and the biological half-lives of d- and l-isomer were 24 hr and 15 hr, respectively.
- 公益社団法人日本薬学会の論文
- 1976-10-25
著者
-
宮崎 浩
寿製薬研究部
-
宮崎 浩
Research Laboratories of Pharmaceuticals Group, Nippon Kayaku Co., Ltd.,
-
阿武木 秀夫
Research Laboratories Pharmaceutical Division Nippon Kayaku Co.
関連論文
- ガスクロマトグラフィー-マススペクトロメトリー(GC/MS)によるプロスタノイド分析のための Diethylhydrogensilyl-Cyclic Diethylsilylene (DEHS-DES) 誘導体 (第2報) : GC 及び GC/MS におけるトロンボキサンB_2 Methyl Ester-Methyloxime-DEHS-DES 誘導体の挙動
- THE DIETHYLHYDROGENSILYL-CYCLIC DIETHYLSILYLIVE DERIVATEVE IN THE GAS CHROMATOGRAPHY-MASS SPECTROMETRY OF THROMBOXANE B_2
- 名誉会員 Evan C. Horning 先生を悼む
- 36 前胸腺によるエクダイソンの生合成
- Isoxazole Derivatives as Centrally Acting Muscle Relaxants. II. : Synthesis and Structure-Activity Relationship of 3-Amino-N-(3-phenyl-5-isoxazolyl)propanamides
- Isoxazole Derivatives as Centrally Acting Muscle Relaxants. I. : Synthesis and Activity of 5-(3-Aminopropyl)amino-3-phenylisoxazole Derivatives
- Antivertigo Agents. V. Quantitative Structure-Activity Relationships of 6-[2-(4-Aryl-1-piperazinyl) ethyl]-5,6,7,8-tetrahydro-1,6-naphthyridines
- Antivertigo Agents. III. Synthesis of 5,6,7,8-Tetrahydro-1,6-naphthyridine Methyl Homologs
- Antivertigo Agents. II. Structure-Activity Relationships of 6-Substituted 5,6,7,8-Tetrahydro-1,6-naphthyridines
- Antivertigo Agents. I. Structure-Activity Relationships of 2-(2-Aminoethyl) pyridines
- Syntheses of Heteroaromatic Carboxylic Acids Closely Related to Fusaric Acid
- Studies on Pyrimidine Derivatives. XIX. Synthesis of Isoxazolo [5,4-d] pyrimidines
- Semisynthesis of ^C-Labelled Leupeptin
- Diethylhydrogensilyl Cyclic Diethylsilylene Derivatives in Gas Chromatography-Mass Spectrometry of Hydroxylated Steroids. II. : Pregnanes with a Hydroxylated 17β-Side-Chain
- 高速液体クロマトグラフィーによる生体試料中エトポシドの定量 : 自動前処理法の開発(医薬品の分析)
- Gas Chromatography-Selected Ion MonitoringによるFM-100投与後の血中グリチルリチン及びグリチルレチン酸の定量
- The Use of a New Silylating Agent for Analysis of Catecholamines by Gas Chromatography-Mass Spectrometry
- よいマススペクトルを得るには (GC-MSの医学・生化学への応用) -- (GC-MSの基礎と測定法)
- Analysis of Bile Acids and Cholesterol by Open Tubular Glass Capillary-Selected Ion Monitoring
- 75 人形峠ウラン鉱床出土植物化石の成分研究
- Use of New Silylating Agents for Identification of Hydroxylated Steroids by Gas Chromatography-Electron Impact-Mass Spectrometry
- Mass Fragmentographic Determination of trans-4-Aminomethylcyclohexanecarboxylic Acid (Tranexamic Acid) by Use of Peak Matching Operation
- Mass Fragmentographic Determination of d- and l-Chlorpheniramine with Aid of the Stable Isotope Technique
- Mass Fragmentographic Determination of 1-Piperidino-2,4'-dimethylpropiophenone (Mydocalm) by Use of 1 : 1 Mixture Technique
- Analysis of Bile Acids by Mass Fragmentography : Application of 1 : 1 Mixture Technique by Use of Stable Isotope labeled Compounds