Semisynthesis of ^<14>C-Labelled Leupeptin
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概要
- 論文の詳細を見る
^<14>C-Labelled leupeptin, Ac-L-[U-^<14>C]-leucyl-L-leucyl-L-argininal, with a specific radioactivity of 20.9 mCi/mmol was prepared by a semisynthetic procedure in which L-leucyl-L-argininal dibutylacetal obtained by an enzymatic cleavage of leupeptin dibutyl-acetal with thermolysin was employed as a key compound. The chemical and radiochemical purities of the labelled leupeptin were found to be over 99% by high performance liquid chromatography using radioisotope and ultraviolet detectors.
- 公益社団法人日本薬学会の論文
- 1982-07-25
著者
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石井 信一
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
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宮崎 浩
Research Laboratories of Pharmaceuticals Group, Nippon Kayaku Co., Ltd.,
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染野 哲也
Research Laboratories, Pharmaceuticals Group, Nippon Kayaku Co., Ltd.,
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才野 哲之
Research Laboratories, Pharmaceutical Division, Nippon Kayaku Co., Ltd.
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石井 信一
Faculty of Pharmaceutical Sciences, Hokkaido University
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染野 哲也
Research Laboratories Pharmaceuticals Group Nippon Kayaku Co. Ltd.
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才野 哲之
Research Laboratories Pharmaceutical Division Nippon Kayaku Co. Ltd.
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宮崎 浩
Research Laboratories Pharmaceutical Division Nippon Kayaku Co. Ltd.
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