STABLE CONFORMATION OF 2,6-CIS-DISUBSTITUTED 1-ACYL-1,2,3,6-TETRAHYDROPYRIDINES AND STEREOSELECTIVE FORMATION OF PALUSTRINE SIDE CHAIN
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The 1-acyl-2,6-cis-disubstituted 1,2,3,6-tetrahydropyridine derivatives (5a-5d) were found to possess the structure of 5-A as a stable conformer. This knowledge was applied to a stereo-controlled formation of the side chain of palustrine (1) by causing an aldehyde (8) to react with Et_2CuLi. A chelated intermediate (8-C) may play an important role in the preferential production of the desired compound (9).
- 公益社団法人日本薬学会の論文
- 1982-09-25
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