TOTAL SYNTHESIS OF NATURAL(+)-DUOCARMYCIN SA

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A total synthesis of natural (+)-duocarmycin SA (1) was achieved as shown in Chart 1,starting from L-malic acid (5) by using a Lewis acid-mediated indole formation reaction of a pyrrole precursor 14 to form the key compound 15.
公益社団法人日本薬学会の論文
1995-06-15

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留学 : 昔と今
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