インドールアルカロイド及び関連化合物合成の最近の展開
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概要
- 論文の詳細を見る
For the purpose of the synthesis of indole alkaloids having alkyl substituents at the benzene portion of the indole, two novel procedures are developed for synthesizing 4,5,6 and/or 7-alkylindole derivatives from pyrrole derivatives. One is a stannic chloride or ptoluenesulfonic acid catalyzed cyclization reaction of compounds 20 and 24,which are synthesized by a stannous chloride mediated reaction of 1-trimethylsily-1,3-butadiene derivatives 23 on the endoperoxide of 1-methoxycarbonylpyrrole 13. Another is a sulfuric acid catalyzed ring cyclization of 1-tosylpyrrole derivatives 74 to afford 4,6 and 7-alkyl substituted indoles. These results are applied to the synthesis of (±)-α-cyclopiazonic acid 5,a mycotoxin isolated first from Penicillium cyclopium, teleocidin A-1 8a and A-2 8b, tumor promoters, and N-alkylergolines and their D-nor or D-homo derivatives, 81,82,and 83.
- 公益社団法人日本薬学会の論文
- 1988-02-25
著者
関連論文
- 留学 : 昔と今
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