Preparation of Alkyl-Substituted Indoles in the Benzene Portion. Part 8. Improved Practical Synthesis of 4,4-Dialkoxy-1-(1-arylsulfonyl-3-pyrrolyl)-1-butanone and 4-(1-Arylsulfonyl-3-pyrrolyl)-4-oxobutanal, and a Novel Synthetic Procedure for 4-Alkoxyindo
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概要
- 論文の詳細を見る
Important precursors (1 and 2) for the synthesis of 4-substituted indole derivatives were readily obtained by acid treatment of a tosylamide (13), which was prepared in a single operation by treatment of 10 with N-tosyl-N', N'-dimethylformamidine (TsN=CHNMe_2). Compound (10) was effectively synthesezed from nitromethane and acrolein by way of a nitro compound (15). A novel indole formation reaction from the tosyl-amide (13) to gain short access to 4-alkoxyindoles, such as 16,17,19,and 21 is presented.
- 公益社団法人日本薬学会の論文
- 1992-09-25
著者
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村竹 英昭
Research Foundation Itsuu Laboratory
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夏目 充隆
Research Foundation Itsuu Laboratory
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宇都宮 岩生
Research Foundation Itsuu Laboratory
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村竹 英昭
Res. Foundation Itsuu Lab. Tokyo Jpn
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