Mutagenicity of Amide Type and Carbamate Type Diazoalkanegenerating Agents in Salmonella/Microsome Assay

概要

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The mutagenicity of several N-nitroso compounds, RCONHCH_2N(NO)R', which were reported as new diazoalkane-generating agents, was assayed by the Salmonella/microsome test. Among 6 amide type N-nitroso compounds which had an alkyl group at position R, only two which had a benzyl group at position R'were weakly mutagenic to Salmonella typhimurium TA100,a base-pair substitution strain, with metabolic activation by S-9 mix. On the contrary, 6 carbamate type N-nitroso compounds which had an alkoxy or benzyloxy group at position R showed considerable mutagenic activity for TA100 with metabolic activation. Two of the carbamate type compounds which had a benzyl group at position R'were also mutagenic in Salmonella typhimurium TA98,a frameshift strain, even without metabolic activation.
公益社団法人日本薬学会の論文
1981-06-25