Determination of End-Point with a Complex Granulation Applying Infrared Moisture Sensor

概要

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A granulation experiment was conducted in a complex granulator, which was fluidized bed equipped with an agitator blade. An infrared moisture sensor was used to feed back control the moisture content of the granule particles.Granule properties (mean particle diameter, geometric standard deviation, yield, apparent density and appearance shape) were examined to know the mechanism and the process of moisture feed back control of the complex granulation.To clear up the factors which determine the mean particle diameter of the granules, the influence of the liquid (binder solution) flow rate, inlet temperature and moisture content were examined to get an experimental equation which expressed the mean particle diameter of the granules. The influence of the moisture content and the rotation speed of the agitator blade on the apparent density was also investigated to get an experimental equation. With the basis of both equations, we established a system which can control the granule mean particle diameter and apparent density using a personal computer, and in addition, a self control system from granulation to drying using an infrared moisture sensor.
公益社団法人日本薬学会の論文
1991-04-25