Modeling and Simulation of Drug Release from Granule Coated with an Aqueous-Based System of Acrylic Copolymer

概要

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In a previous paper, [Watano et al., Chem. Pharm. Bull., 42,2338 (1994)], we proposed a simple model which could be used to analyze data of controlled release of a water-soluble drug from spherical particles coated with an aqueous-based system of acrylic copolymer by a tumbling fluidized bed process. The model predicted that the fractional release of drug was related to exponential of release time, and drug release data of several samples prepared with various levels of operational moisture content were studied to determine the effect of this content on film thickness and drug permeability.In this study, to confirm the method's validity, we simulated the drug release rate at various moisture content and coating levels using the proposed model. The simulated results were compared with the experimental data to evaluate the accuracy of the model. The mechanism of aqueous coating was also described using the simulated results.
公益社団法人日本薬学会の論文
1995-05-15