攪拌造粒の造粒終点決定方法及び粉末コーティング

概要

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An experimental investigation on the end-point for the granulation process by which spherical and well-compacted granules are obtained in high yield was carried out. Power consumption of a needer mixer was measured during granulation. The tensile strength, shape index and bulk density of granules obtained were measured. Powder coating on wet spherical granules was also attempted. The end-point for granulation to obtain spherical and well-compacted granules in high yield was found when the power consumption for granulation reaches constant value. Spheronization of granules occurred before compaction of granules. The binder content and impeller speed necessary for the production of spherical, well-compacted granule in high yield were also studied. A method of powder coating, in which a powdered coating material dusted onto wet spherical granules at the end point of granulation utilizing the liquid film on the granules is formed by exudation of a binder solution, was devised.
公益社団法人日本薬学会の論文
1985-12-25