Analysis of End-Point with Power Consumption in High Speed Mixer

概要

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A granulation experiment was conducted using different granulator and formulation. The purpose of the experiment was to clarify the granulation end-point to gain high yields of spherical, well-compacted granules and fine granules, and to investigate the agitation-granulating process. The fluctuation of electric-power consumption was continuously measured during the granulation operation, and it was determined that measurement of power consumption was helpful for determining the granulation process and granulation end point.One of the results of the experiment was that the granulation process was divided into four phases, and at the initial stage of phase IV high yields of spherical, well-compacted granules and fine granules are possibly produced (granulation end-point). It was found that the granulating mechanisms in each of the phases is not affected by the use of different agitation granulators, formulations, or the binder addition time adopted. The specific binder addition time and granulator model that produced high yields of granules and fine granules were identified.
公益社団法人日本薬学会の論文
1990-07-25