Synthesis of 1H-Imidazo[1,2-a]pyrazolo[3,4-c]pyridines
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概要
- 論文の詳細を見る
The reaction of nitrosyl chloride with 6- and 8-acetamido-7-methylimidazo[1,2-a]pyridine (7g-i) reveal clear differences of reactivity of these isomeric structures. After bifunctionalization of the imidazolic moiety, the 6-acetamido derivatives do not yield the 1H-imidazo[1,2-a]pyrazolo[4,5-d]pyridine (4) system, but undergo a Gomberg-Bachman reaction complicated by Dimroth rearrangement. In contrast, upon similar treatment, the 8-acetamido compounds (17,19) yielded the N-nitrosoacetamides (18a, b), which were converted into 1H-imidazo[1,2-a]pyrazolo[3,4-c]pyridines (20a, b) in 22 and 34% yields, respectively, without rearrangement.
- 公益社団法人日本薬学会の論文
- 1990-09-25
著者
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CHAVIGNON Olivier
Laboratoire de Chimie Organique, Faculte de Pharmacie
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CHAVIGNON Olivier
Faculte de Pharmacie UMR-INSERM 484
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GUEIFFIER Alain
Laboratoire de Chimie Therapeutique SPOT EA 3857, Faculte de Pharmacie
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BLACHE Yves
Laboratoire de Chimie Organique Pharmaceutique, UMR-INSERM 484, Faculte de Pharmacie
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Blache Yves
Laboratoire De Chimie Organique Pharmaceutique Ura-cnrs 1111 Faculte De Pharmacie
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TEULADE Jean
Laboratoire de Chime Organique Pharmaceutique, UFR de Pharmacie
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CHAPAT Jean
Laboratoire de Chimie Organique Pharmaceutique, UA 1111, Faculte de Pharmacie
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Chapat Jean
Laboratoire De Chimie Organique Pharmaceutique Ura-cnrs 1111 Faculte De Pharmacie
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Teulade Jean
Laboratoire De Chimie Organique Pharmaceutique Groupe De Recherche En Pharmacochimie Ufr De Pharmaci
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DAUPHIN Gerard
Laboratoire de Chimie Organique Biologique
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Dauphin G
Laboratoire De Chimie Organique Biologique Ura 485 Cnrs
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MILHAVET Jean
Laboratoire de Chimie Organique Pharmaceutique, URA-CNRS 1111, Faculte de Pharmacie
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MADESCLAIRE Michel
Laboratoire de Chimie Organique Pharmaceutique, Groupe de Recherche en Pharmacochimie, UFR de Pharma
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VIOLS Henry
Laboratoire de Chimie Organique Pharmaceutique, URA-CNRS 1111, Faculte de Pharmacie
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Viols H
Facult´e De Pharmacie Montpellier Fra
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Milhavet Jean
Laboratoire De Chimie Organique Pharmaceutique Ura-cnrs 1111 Faculte De Pharmacie
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Chavignon Olivier
Laboratoire De Chimie Organique Pharmaceutique Groupe De Recherche En Pharmacochimie Ufr De Pharmaci
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Madesclaire Michel
Laboratoire De Chimie Organique Pharmaceutique Groupe De Recherche En Pharmacochimie Ufr De Pharmaci
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Gueiffier Alain
Laboratoire De Chimie Organique Pharmaceutique Ura-cnrs 1111 Faculte De Pharmacie
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Gueiffier Alain
Laboratoire De Chimie Organique Pharmaceutique Ua 1111 Faculte De Pharmacie
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