Analogs of Monensin with a Modified C_<25>-C_<26> Moiety : Na^+/K^+ Selectivity and Biological Activity(Organic Chemistry)

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概要

• 論文の詳細を見る

• C_<25>-C_<26> chemical derivatives of monensin (1) were prepared: 25-dehydroxymethyl, 25-oxo (2); 25,26-isopropyliden (3); 25-O-methyl (4); 26-O-acyl (5); 26-O-[N-chlorophenyl]carbamoyl (6); and 26-O-N-chlorophenyl, N-methyl]carbamoyl (7). Measurements of Na^+ and K^+ extractions in a water/toluene-butanol (70:30) system by these analogs showed the key role of the C_<26>H_2-OH arm for the stability and selectivity of 1:1 complexes formed by monensin. The antibiotic activity and toxicity in mice were determined in relation to the Na^+ /K^+ cationic affinity.

• 社団法人日本農芸化学会の論文
• 1990-05-23

著者

• DAUPHIN Gerard

  Laboratoire de Chimie Organique Biologique

• JEMINET Georges

  Laboratoire de Synthese, Electrosynthese et Etude de Systemes a Interet Biologique, Universite Blais

• Dauphin Gerard

  Laboratoire De Chimie Organique Biologique U.k.a. 485 Du C.n.r.s. Universite Blaise Pscal

• GABOYARD Catherine

  Laboratoire de Chimie Organique Biologique, U.K.A. 485 du C.N.R.S., Universite Blaise Pscal

• VAUFREY Francoise

  Laboratoire de Chimie Organique Biologique, U.K.A. 485 du C.N.R.S., Universite Blaise Pscal

• Vaufrey Francoise

  Laboratoire De Chimie Organique Biologique U.k.a. 485 Du C.n.r.s. Universite Blaise Pscal

• Gaboyard Catherine

  Laboratoire De Chimie Organique Biologique U.k.a. 485 Du C.n.r.s. Universite Blaise Pscal

• Jeminet Georges

  Laboratoire De Chimie Organique Biologique U.k.a. 485 Du C.n.r.s. Universite Blaise Pscal

関連論文

• Nigericic Acids, Two New Chemical Derivatives of Nigericin(Organic Chemistry)
• Ionophore Properties of Cationomycin in Large Unilamellar Vesicles Studied by ^Na- and ^K-NMR
• Synthesis of 1H-Imidazo[1,2-a]pyrazolo[3,4-c]pyridines
• Analogs of Monensin with a Modified C_-C_ Moiety : Na^+/K^+ Selectivity and Biological Activity(Organic Chemistry)

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