Ionophore Properties of Cationomycin in Large Unilamellar Vesicles Studied by ^<23>Na- and ^<39>K-NMR

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概要

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• Cationomycin, isolated from Actinomadura azurea belongs to a large family of carboxylic polyehter antibiotics, transporting monovalent cations through membranes by a mobile carrier mechanism, leading globally to an H^+, M^+ exchange.In this report the cation transporting properties of cationomycin were characterized in large unilamellar vesicles (LUVs) by ^<23>Na- and ^<39>K-NMR. Kinetic studies showed that cationomycin transported potassium more rapidly than sodium, and the more stable complex was formed with potassium at the water/membrane interface. The transport rate constants measured for cationomycin were compared with those obtained for monensin. Cationomycin transports Na^+ more slowly than monensin and has a lower stability complex with Na^+ because of the lower formation rate for the complex on the membrane surface. Our results show that transport selectivity of cationomycin is in favour of K^+ versus Na^+ while the reverse situation is observed for monensin.The relationships between the ionophore properties of cationomycin and monensin with their biological activities are discussed.

• 公益社団法人日本薬学会の論文
• 1998-10-15

著者

• Delort Anne-Marie

  Laboratoire de Synthese Et Etudes de Systemes a Interets Biologiques (SEESIB)

• Delort Anne-marie

  Laboratoire De Synthese Electrosynthese Et Etude De Systemes A Interet Biologique Universite Blaise

• JEMINET Georges

  Laboratoire de Synthese, Electrosynthese et Etude de Systemes a Interet Biologique, Universite Blais

• SARETH Sina

  School of Chemistry, The University of St Andrews

• RIDDLE Frank

  School of Chemistry, The University of St Andrews

• Jeminet Georges

  Laboratoire De Chimie Organique Biologique U.k.a. 485 Du C.n.r.s. Universite Blaise Pscal

• Jeminet Georges

  Laboratoire De Synthese Electrosynthese Et Etude De Systemes A Interet Biologique Universite Blaise

• Riddle Frank

  School Of Chemistry The University Of St Andrews

• Sareth Sina

  School Of Chemistry The University Of St Andrews

関連論文

• The study of the mercury cycle in polar regions: An international study in Ny-Alesund, Svalbard
• Ionophore Properties of Cationomycin in Large Unilamellar Vesicles Studied by ^Na- and ^K-NMR
• Analogs of Monensin with a Modified C_-C_ Moiety : Na^+/K^+ Selectivity and Biological Activity(Organic Chemistry)

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