Regioselective Synthesis of Pyrazolo[4,5-g]pyrido[1,2-a]benzimidazoles : Cytotoxic Derivatives of Pyrido[1,2-a]benzimidazolic Ring System
スポンサーリンク
概要
- 論文の詳細を見る
N-1 and N-2 substituted pyrazolo[4,5-g]pyrido[1,2-a]benzimidazoles were prepared regioselectively, and cytotoxicities evaluated in vitro against K562 and HL60 cells. All compounds displayed weaker activity than doxorubicin against sensitive lines, but showed the same activity against resistant cell lines (multidrug resistance +, (MDR^+); K562R and HL60R) indicating no resistance phenomena.
- 公益社団法人日本薬学会の論文
- 1998-11-15
著者
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Chezal Jean-michel
Laboratoire De Chimie Organique Ea 3660 Faculte De Pharmacie
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CHAVIGNON Olivier
Laboratoire de Chimie Organique, Faculte de Pharmacie
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TEULADE Jean-Claude
Laboratoire de Chimie Organique, Faculte de Pharmacie
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Chapat J‐p
Fac. De Pharmacie Montpellier Fra
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CHAVIGNON Olivier
Faculte de Pharmacie UMR-INSERM 484
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BLACHE Yves
Laboratoire de Chimie Organique Pharmaceutique, UMR-INSERM 484, Faculte de Pharmacie
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CHAPAT Jean-Pierre
Laboratoire de Chimie Organique Pharmaceutique
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DUPUY Marianne
Laboratoire de Chimie organique Pharmaceutique
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PINGIET Frederic
Laboratoire d' oncopharmacologie, Centre Regional de Lutte contre le Cancer
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Dupuy Marianne
Laboratoire De Chimie Organique Pharmaceutique:laboratoire D'oncopharmacologie Centre Regional
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Chavignon O
Ufr De Pharmacie Clermont‐ferrand Fra
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Blache Y
Laboratoire De Chimie Organique Pharmaceutique Umr-inserm 484 Faculte De Pharmacie
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Blache Yves
Laboratoire De Chimie Organique Pharmaceutique Ura-cnrs 1111 Faculte De Pharmacie
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Teulade J‐c
Laboratoire De Chimie Organique Ea 3660 Faculte De Pharmacie
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Teulade Jean-claude
Laboratoire De Chimie Organique Ea 3660 Faculte De Pharmacie
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Pinguet Frederic
Laboratoire D'oncopharmacologie Centre Regional De Lutte Contre Le Cancer
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Pinguet Frederic
Laboratoire D'onco-pharmacologie Centre Regional De Lutte Contre Le Cancer
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Chavignon Olivier
Laboratoire De Chimie Organique Pharmaceutique Groupe De Recherche En Pharmacochimie Ufr De Pharmaci
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Teulade Jean-claude
Laboratoire De Chimie Organique Faculte De Pharmacie
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