Synthesis and in Vitro Cytotoxic Evaluation of New Derivatives of Pyrido[1, 2-a]benzimidazolic Ring System : The Pyrido[1', 2':1, 2]imidazo[4, 5-h]quinazolines
スポンサーリンク
概要
- 論文の詳細を見る
Access to the original series of pyrido[1', 2':1, 2]imidazo[4, 5-h]quinazoline was developed from a 1, 3-dicarbonyl unit with some "N-C-N" bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytotoxic activities against HL60 and A2780 cells. All compounds exhibited cytotoxic activities on resistant cell lines (MDR^+;HL60R and A2780R) with no resistance phenomena.
- 公益社団法人日本薬学会の論文
- 2001-09-01
著者
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Chezal Jean-michel
Laboratoire De Chimie Organique Ea 3660 Faculte De Pharmacie
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CHAVIGNON Olivier
Laboratoire de Chimie Organique, Faculte de Pharmacie
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TEULADE Jean-Claude
Laboratoire de Chimie Organique, Faculte de Pharmacie
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Chapat J‐p
Fac. De Pharmacie Montpellier Fra
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CHAVIGNON Olivier
Faculte de Pharmacie UMR-INSERM 484
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PINGUET Frederic
Laboratoire d'Oncopharmacologie, Centre Regional de Lutte Contre le Cancer
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BLACHE Yves
Laboratoire de Chimie Organique Pharmaceutique, UMR-INSERM 484, Faculte de Pharmacie
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CHAPAT Jean-Pierre
Laboratoire de Chimie Organique Pharmaceutique
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DUPUY Marianne
Laboratoire de Chimie organique Pharmaceutique
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Dupuy Marianne
Laboratoire De Chimie Organique Pharmaceutique:laboratoire D'oncopharmacologie Centre Regional
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Chavignon O
Ufr De Pharmacie Clermont‐ferrand Fra
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Blache Y
Laboratoire De Chimie Organique Pharmaceutique Umr-inserm 484 Faculte De Pharmacie
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Blache Yves
Laboratoire De Chimie Organique Pharmaceutique Ura-cnrs 1111 Faculte De Pharmacie
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Teulade J‐c
Laboratoire De Chimie Organique Ea 3660 Faculte De Pharmacie
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Teulade Jean-claude
Laboratoire De Chimie Organique Ea 3660 Faculte De Pharmacie
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Pinguet Frederic
Laboratoire D'oncopharmacologie Centre Regional De Lutte Contre Le Cancer
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Pinguet Frederic
Laboratoire D'onco-pharmacologie Centre Regional De Lutte Contre Le Cancer
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Chavignon Olivier
Laboratoire De Chimie Organique Pharmaceutique Groupe De Recherche En Pharmacochimie Ufr De Pharmaci
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Teulade Jean-claude
Laboratoire De Chimie Organique Faculte De Pharmacie
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