Studies on the Imidazo[1,2-α]pyridinic System : Synthesis of Pyrido[1', 2', : 1,2]imidazo[5,4-d][1.3]-benzodiazepines

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概要

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• 3-Nitroso-2(2-nitrophenyl)imidazo[1,2-α]pyridine was converted to its diamino derivative (5) and the open-chain compound 2-N(2-pyridyl)benzimidoyl cyanide (6). Compound 5 was condensed with triethyl orthoformate or 2-chlorobenzaldehyde to afford the pyrido[1', 2' : 1,2]imidazo[5,4-d][1.3]benzodiazepines (7a, b). X-Ray crystallographic analysis confirmed the structure of 7a. The structure of 7b was assigned by two-dimensional nuclear magnetic resonance techniques, ^1H-^1H and ^<13>C-^1H correlatino spectroscopy.

• 公益社団法人日本薬学会の論文
• 1989-09-25

著者

• GUEIFFIER Alain

  Laboratoire de Chimie Therapeutique SPOT EA 3857, Faculte de Pharmacie

• Grassy G

  Dep. Chimie Pharmaceutique Toulouse Fra

• TEULADE Jean

  Laboratoire de Chime Organique Pharmaceutique, UFR de Pharmacie

• CHAPAT Jean

  Laboratoire de Chimie Organique Pharmaceutique, UA 1111, Faculte de Pharmacie

• GRASSY Gerard

  Department de Chimie Phamaceutique, Faculte des Sciences Pharmaceutiques, Universite Paul Sabatier

• CARPY Alain

  UA-CNRS 605, UER des Sciences Pharmaceutiques

• PERLY Bernard

  CEA-IRDI

• COUQUELET Jacques

  DESICP

• Carpy Alain

  Ua-cnrs 605 Uer Des Sciences Pharmaceutiques

• Chapat J

  Fac. Pharmacie Montpellier Fra

• Chapat Jean

  Laboratoire De Chimie Organique Pharmaceutique Ura-cnrs 1111 Faculte De Pharmacie

• Teulade J

  Ufr De Pharmacie Clermont‐ferrand Fra

• Gueiffier Alain

  Laboratoire De Chimie Organique Pharmaceutique Ua 1111 Faculte De Pharmacie

関連論文

• 3-Benzamido, Ureido and Thioureidoimidazo[1, 2-a]pyridine Derivatives as Potential Antiviral Agents
• From the Particular Reactivity of 8-Iodoimidazo[1,2-a]pyridine towards Copper- and Palladium-Catalyzed Aminations
• Synthesis of Diaryl-Substituted Imidazo[1,2-a]pyridines Designed as Potential Aromatase Inhibitors
• Studies on the Imidazo[1,2-α]pyridinic System : Synthesis of Pyrido[1', 2', : 1,2]imidazo[5,4-d][1.3]-benzodiazepines
• Synthesis of 1H-Imidazo[1,2-a]pyrazolo[3,4-c]pyridines
• Synthesis and Antibacterial Activity of Some Imidazo [1,2-α]pyrimidine Derivatives
• Evaluation of the 2-Substituent Effect on the Reactivity of the 8-Haloimidazo[1, 2-a]pyridine Series towards Suzuki-Type Cross-Coupling Reaction

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