Synthesis of Diaryl-Substituted Imidazo[1,2-a]pyridines Designed as Potential Aromatase Inhibitors

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概要

• 論文の詳細を見る

• From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1,2-a]pyridine derivatives. The synthesis and the spectroscopy determination of various compounds are reported. The crystal data of one of these compounds (10b) was obtained. The aromatase inhibition potency was evaluated in vitro and no activity was found.

• 公益社団法人日本薬学会の論文
• 2000-07-01

著者

• ALLOUCHI Hassan

  Laboratoire de Chimie Physique, Faculte de Pharmacie

• ENGUEHARD Cecile

  BCM

• GUEIFFIER Alain

  Laboratoire de Chimie Therapeutique SPOT EA 3857, Faculte de Pharmacie

• ENGUEHARD Cecile

  Laboratoire de Chimie Therapeutique, UFR des Sciences Pharmaceutiques

• RENOU Jean-Louis

  Laboratoire de Chimie Therapeutique, UFR des Sciences Pharmaceutiques

• LEGER Jean-Michel

  Laboratoire de Chimie Physique et Radiocristallographie, Universite Bordeaux II

• Allouchi Hassan

  Laboratoire De Chimie Physique Faculte De Pharmacie

• Renou Jean-louis

  Laboratoire De Chimie Therapeutique Ufr Des Sciences Pharmaceutiques

• Gueiffier A

  E.a.groupe De Recherche En Chimie Heterocyclique Et Therapeutique Laboratoire De Chimie Therapeutiqu

• Gueiffier Alain

  Laboratoire De Chimie Organique Pharmaceutique Ua 1111 Faculte De Pharmacie

• Enguehard Cecile

  Laboratoire de Chimie Therapeutique SPOT EA 3857, Faculte de Pharmacie

関連論文

• 3-Benzamido, Ureido and Thioureidoimidazo[1, 2-a]pyridine Derivatives as Potential Antiviral Agents
• From the Particular Reactivity of 8-Iodoimidazo[1,2-a]pyridine towards Copper- and Palladium-Catalyzed Aminations
• Synthesis of Diaryl-Substituted Imidazo[1,2-a]pyridines Designed as Potential Aromatase Inhibitors
• Studies on the Imidazo[1,2-α]pyridinic System : Synthesis of Pyrido[1', 2', : 1,2]imidazo[5,4-d][1.3]-benzodiazepines
• Synthesis of 1H-Imidazo[1,2-a]pyrazolo[3,4-c]pyridines
• Evaluation of the 2-Substituent Effect on the Reactivity of the 8-Haloimidazo[1, 2-a]pyridine Series towards Suzuki-Type Cross-Coupling Reaction

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