Evaluation of Valving System Influence on the Spray Characteristics of an Aerosol Formulation Consisting of Kerosene/Propane/Butane

概要

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The influence of formulation factors, particularly the valving system, on the spray characteristics such as spray-droplet size and delivery rate were evaluated using aerosol formulations consisting of kerosene and a mixture of propane/butane. The liquid/propellant ratio was fixed at 60/40 by weight and the pressure of the propellant was 4.8 kg/cm^2 (gauge) at 20℃. The spray-droplet size was measured by using the laser-diffraction drop-sizing method. The sizes of the three orifices in the valving system (stem orifice [ST], vapor-phase tap orifice [VT] and actuator orifice [BU]) affected both the spray-droplet size and the delivery rate. The bigger the size of ST and BU and the samaller the size of VT, the greater the delivery rate. The spray-droplet size was affected by the mutual interactions among ST, BU and VT. The spray-droplet size dcreased as the size of VT increased when ST was larger than BU or was not much smaller than BU. The effect of VT to reduce spray-droplet size did not appear when BU was too much larger than ST. When VT was small enough or absent, the smallest spray-droplet size was obtained when the ST/BU ratio was around one. When VT was large, the spray-droplet size decreased as the ST/BU ratio increased. It was concluded that the balance of sizes of the three orifices was very important to obtain the most suitable spray characteristics.
公益社団法人日本薬学会の論文
1989-10-25