Interaction of Theophylline with L-Tryptophan. Study by Proton Nuclear Magnetic Resonance Spectroscopy
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概要
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The interaction of theophylline with L-tryptophan was investigated in aqueous solution adjusted to ionic strength 0.20,at pD 6.2,by using proton nuclear magnetic resonance spectroscopy. Theophylline interacted with L-tryptophan at a molar ratio of 1 : 1 by parallel stacking. The thermodynamic parameters obtained for the complexation were as follows : ΔG°=-1.52kcal/mol (K=13.1M^<-1>), ΔH°=-5.1kcal/mol, ΔS°=-12.3 e.u. It was found that the driving force for parallel stacking is a combination of electrostatic, polarization, and dispersion interactions, and the contribution of hydrophobic bonding is small. A possible stacking mode is postulated, based on the complexation shifts and π-electron charge distributions of theophylline and L-tryptophan.
- 公益社団法人日本薬学会の論文
- 1988-08-25
著者
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杉浦 真喜子
Kobe Women's College of Pharmacy
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杉浦 真喜子
Kobe Women's College Of Pharmacy
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西庄 重次郎
Kobe Women's College of Pharmacy
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岩本 恵美子
Kobe Women's College of Pharmacy
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米谷 郁子
Kobe Women's College of Pharmacy
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戸倉 さつき
Kobe Women's College of Pharmacy
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米谷 郁子
Kobe Women's College Of Pharmacy
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西庄 重次郎
Kobe Women's College Of Pharmacy
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岩本 恵美子
Kobe Women's College Of Pharmacy
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戸倉 さつき
Kobe Women's College Of Pharmacy
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