Interaction of 8-Anilinonaphthalene-1-sulfonate with α-Cyclodextrin

概要

論文の詳細を見る
The interaction of 8-anilinonaphthalene-1-sulfonate (ANS) with α-cyclodextrin was investigated in a 0.1M phosphate buffer at pH 7.4 by fluorescence spectrophotometry. Utilizing the fact that the fluorescence intensity of ANS increases in the presence of α-cyclodextrin, the thermodynamic parameters for inclusion complex formation were determined as folloews; ΔG°=-1.25kcal/mol at 25℃, ΔH°=-3.0kcal/mol, ΔS°=-5.8e.u. The driving force for the inclusion complex formation was cosidered to be the van der Waals-London dispersion force and hydrogen bonding between -SO^-_3 of ANS and the secondary hydroxyl groups of α-acyclodextrin.Also, from the measurements of proton nuclear magnetic resonance spectra and studies with Corey Pauling Koltun models, the probable structure was determined.
社団法人日本薬学会の論文
1991-01-25