Soluble Complex Formation of Theophylline with Aliphatic Di-and Monoamines in Aqueous Solution

概要

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The interactions of theophylline with aliphatic diamines and aliphatic monoamines were studied by measurements of solubility in aqueous solution. Diamines such as 1,3-propanediamine, 1,4-butanediamine, 1,6-hexanediamine and ethylenediamine, and monoamines such as triethylamine, diethylamine, n-propylamine, allylamine, 2-methoxylamine, ethanolamine and triethanolamine were used. The solubility of theophylline increased in the presence of amine and increased in proportion to the pK_a of the amine. The amount of the complex formed was found to be proportional to the pK_a of the amine and the apparent stability constant of complex formation tended to increase as the pK_a of the amine increased.
公益社団法人日本薬学会の論文
1982-03-25