Influence of Temperature and Ionization on Self-Association of Theophylline in Aqueous Solution. Studies by Proton Nuclear Magnetic Resonance Spectroscopy
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概要
- 論文の詳細を見る
Thermodynamic parameters for self-association of theophylline in aqueous solution adjusted to ionic strength 0.20 were determined by proton unclear magnetic resonance spectroscopy. The results obtained at pD 5.8 were as follows : ΔG°=-0.95kcal/mol at 30℃ (K=4.8M^<-1>), ΔH°=-6.3kcal/mol, and ΔS°=-18e.u. It was found that the driving force for self-association involves electrostatic, polarization, and dispersion interactions, and the contribution of hydrophobic bonding is small. A possible mode of self-association of theophylline is postulated. It was found that self-association of theophylline occurs more easily in the neutral state than in the ionized state.
- 公益社団法人日本薬学会の論文
- 1986-11-25
著者
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田ヶ原 清
Kobe Women's College of Pharmacy
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西庄 重次郎
Kobe Women's College of Pharmacy
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鈴田 幸男
Kobe Women's College of Pharmacy
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岩本 恵美子
Kobe Women's College of Pharmacy
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米谷 郁子
Kobe Women's College of Pharmacy
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米谷 郁子
Kobe Women's College Of Pharmacy
-
西庄 重次郎
Kobe Women's College Of Pharmacy
-
岩本 恵美子
Kobe Women's College Of Pharmacy
-
田ヶ原 清
Kobe Women's College Of Pharmacy
-
鈴田 幸男
Kobe Women's College Of Pharmacy
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