Structure-Activity Relationship for Antibacterial Action of Phenolic and Aromatic Nitro Compounds. An Attempt at Systematic Identification of New Antibacterial Agents
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概要
- 論文の詳細を見る
A structure-activity relationship between antibacterial activity and the energy of the lowest unoccupied molecular orbital (LUMO) of phenolic and aromatic nitro compounds was derived based on results obtained with eight strains of Gram-positive and Gram-negative bacteria. The reliability of the correlation was confirmed by measuring the minimum inhibitory concentration at various pH values of the medium ; it was found that the undissociated molecular species having a low lying LUMO is essential for strong antibacterial activity. Based on the above results, 2,4,6-trinitroanisole was examined, and it proved to have a remarkably strong antibacterial activity (200 times stronger than that of 2,4,6-trinitrophenol).
- 公益社団法人日本薬学会の論文
- 1985-07-25
著者
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Niiho Yujiro
福岡大学 薬学部
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Nakajima Yoshijiro
福岡大学 薬学部
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津田 穣
千葉大・薬
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笈川 節子
千葉大学薬学部
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中島 良徳
北海道薬科大学微生物学研究室
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松岡 真由美
Division Of Microbiology Hokkaido Institute Of Pharmaceutical Sciences
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遠藤 菊太郎
北海道薬科大学微生物学研究室
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中島 良徳
Division of Microbiology, Hokkaido Institute of Pharmaceutical Sciences
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津田 穣
Laboratory of Physical Chemistry, Faculty of Pharmaceutical Sciences, Chiba University
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Nakajima Y
Tsukuba Research Institute Ohta's Isan Co. Ltd.
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Niiho Yujiro
Tsukuba Research Institute
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