Effect of Fluid Volume on the Gastric Emptying and Absorption of Quinine in Mice, Rabbits and Humans

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The effect of coadministered fluid volume on the gastrointestinal absorption of quinine was investigated in mice, rabbits and humans. In mice, an increase in fluid volume from 5 to 40ml/kg resulted in a significant increase in the maximum plasma quinine concentration (C_<max>) ; the time required to reach C_<max> (T_<max>) was reduced. However, fluid volume had little effect on the area under the plasma concentration-curve (AUC_<0→180>). The gastric emptying of quinine in the initial stage after administration increased in proportion to the fluid volume. These results indicate that in mice, an increase in fluid volume enhances the rate of gastrointestinal absorption of quinine by producing an early increase of the gastric emptying. In rabbits, quinine was introduced via a tube into the washed and emptied stomach ; an increase in fluid volume had little effect on C_<max>, T_<max> and AUC of quinine. Furthermore, the fluid volume did not affect the gastric emptying rate. In humans, C_<max>, T_<max> and AUC of quinine after oral administration were not affected even when the fluid volume was increased from 20 to 500ml. These results show that in mice, the effect of fluid intake on gastric emptying is different from that in rabbits and humans.
公益社団法人日本薬学会の論文
1984-08-25