Crohn 病の低亜鉛血症に関する検討

概要

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Measurement of serum zinc concentration on admission, zinc balance study and zinc loading test (oral administration of 40mg of zinc) performed during ED therapy using naso-duodenal feeding tube were carried out in 18 patients with Crohn's disease of non-operated cases and 8 normal controls.In the patients with Crohn's disease, a positive correlation between zinc and albumin levels of the serum, and a negative correlation between serum zinc level and activity index (CDAI, Dutch AI) were observed. These correlations were significant.A significant positive correlation was observed between AUC (area under the curve) and srum zinc level, howerver correlation was not observed between AUC and serum albumin level just before zinc loading test in the patients with Crohn's disease.These results suggest that disturbance of zinc absorption from intestinal tract is the main cause of the low level of serum zinc in Crohn's disease and it is effected by the activity of this disease.
財団法人日本消化器病学会の論文