マウスにおけるチオペンタールナトリウムおよびアミノピリンの胃内容排出ならびに消化管吸収におよぼす投与液量の影響

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The influence of coadministered fluid volume on pharmacological response, gastrointestinal absorption and gastric emptying of thiopental-Na and aminopyrine after oral administration was examined in mice. When the coadministered fluid volume increased from 4 to 20 ml/kg, the hypnotic effect of thiopental-Na and analgetic effect of aminopyrine increased in proportion to fluid volume. And also the remaining percentages of these drugs in gastrointestine were reduced with an increase in fluid volume. These drugs in the stomach after oral administration were transferred to the small intestine at a relatively fast rate in the initial stage and then gradually evacuated according to exponential process. This fast gastric emptying in the initial stage was accelerated in proportion to fluid volume, however, the gastric emptying rate evacuated expornentially with time was not influenced by the increase of fluid volume. From these results, it was defined that the acceleration of gastric emptying in the initial stage due to the increase of fluid volume enhanced the absorption rate of drugs in the small intestine and that the pharmacological effect. In conclusion, it was shown that a great care should be taken for the fluid volume accompanying the extract of pharmacological response of drug by use of a small animal.
公益社団法人日本薬学会の論文
1981-06-25

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