Effect of Carbachol on Intestinal Absorption of Aminopyrine, Caffeine and Salicylic Acid during in Situ Recirculating Perfusion in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effect of carbachol on the absorptions of caffeine, aminopyrine and salicylic acid in the rat small intestine was studied, using an in situ recirculating perfusion method. Carbachol, either added to the perfusate or injected intravenously, remarkably reduced drug absorption. Upon the addition of carbachol, the perfusate volume of intestine decreased markedly and there was a positive correlation between the perfusate volume and the drug absorption rate. No physicochemical interaction, as determined by measurement of the partition coefficient between isoamyl acetate or benzene and phosphate buffer (pH 7.0), was noted between the drugs and carbachol in solution. Our results suggest that the carbachol-induced decrease in drug absorption is due to a reduction in the perfusate volume in the intestine upon recirculating perfusion.
- 公益社団法人日本薬学会の論文
- 1981-07-25
著者
-
都築 脩三
第一薬科大学
-
都築 脩三
Daiichi College of Pharmaceutical Sciences
-
河野 喜美彦
Daiichi College of Pharmacy
-
田中 八州宏
Daiichi College of Pharmacy
-
秋吉 秀尚
Daiichi College Pharmacy
関連論文
- ヒトおよび小児てんかん患者におけるカルバマゼンの血漿および唾液中濃度(発表論文抄録(1986年))
- 薬物のヒト赤血球膜透過性へのHuman Serum Albuminの影響
- Promotion of Rectal Absorption of Sodium Ampicillin by Disodium Glycyrrhetinic Acid 3β-O-Monohemiphthalate in Rats
- Modeling of Controlled Release of Aspirin Derivatives from Human Erythrocytes
- Effect of Fluid Volume on Gastric Emptying and Intestinal Drug Absorption. II. Dihydrocodeine and Thiopental Concentration Profiles in Plasma after Oral Administration in Different Fluid Volumes to Mice
- Effect of Fluid Volume on the Gastric Emptying and Absorption of Quinine in Mice, Rabbits and Humans
- Effect of Carbachol on Intestinal Absorption of Aminopyrine, Caffeine and Salicylic Acid during in Situ Recirculating Perfusion in Rats
- マウスにおけるチオペンタールナトリウムおよびアミノピリンの胃内容排出ならびに消化管吸収におよぼす投与液量の影響
- Crohn 病の低亜鉛血症に関する検討