PERMEABILITY OF GLYCOSIDES THROUGH HUMAN ERYTHROCYTE MEMBRANE
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概要
- 論文の詳細を見る
The permeability of glycosides (arbutin, salicin, glycyrritin, p-nitrophenyl-β-D-glucopyranoside, p-nitrophenyl-β-D-galactopyranoside, p-nitrophenyl-β-D-lactopyranoside, p-nitrophenyl-β-D-maltopyranoside) and their aglycons through human erythrocyte membrane was investigated. The glycosides permeated slowly, compared with their aglycons. Glycoside having disaccharide did not permeate the erythrocyte membrane. This suggested that the introduction of disaccharide to a drug significantly depresses the permeability of glycoside through erythrocyte membrane. The drug entrapped in erythrocytes was not released into the outer medium.
- 公益社団法人日本薬学会の論文
- 1991-05-25
著者
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大迫 雅彦
Department of Pharmacy, Daiichi College of Pharmaceutical Sciences
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松本 康裕
Department of Pharmacy, Daiichi College of Pharmaceutical Sciences
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松本 康裕
第一薬科大学薬剤学教室
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坂田 律
Department Of Pharmacy Daiichi College Of Pharmaceutical Sciences
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松本 康裕
第一薬科大学
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大迫 雅彦
第一薬科大学薬剤学教室
関連論文
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- Modeling of Controlled Release of Aspirin Derivatives from Human Erythrocytes
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- PERMEABILITY OF GLYCOSIDES THROUGH HUMAN ERYTHROCYTE MEMBRANE
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