Preparation and Spectrochemical Investigation of Copper (II), Nickel (II), Cobalt (II), and Zinc (II) Complexes of 2-Hydrazino-4-hydroxy-6-methylpyrimidine

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Copper (II), cobalt (II), nickel (II), and zinc (II) complexes of 2-hydrazino-4-hydroxy-6-methylpyrimidine were synthesized, and their infrared (IR) and nuclear magnetic resonance (NMR) spectra were examined. In the IR spectra of the complexes, the amide-I (carbonyl) bands were present and it was assumed that the ligand molecules were coordinated in the keto form of the isocytosine ring. The low frequency shift of the NH_2 stretching bands by about 40-45 cm^<-1> on combining with Cu and Co indicated the formation of a metal-nitrogen bond. Preferential broadening of methine proton to methyl proton in the NMR spectra of the complexes of 2-hydrazino-4-hydroxy-6-methylpyrimidine can be explained by the binding of Co (II), Cu (II), and Ni (II) to N (3) site of the isocytosine ring. An ESR spectrum of the copper (II) complex would suggest the presence of copper (II) ion in a square-pyramidal conformation.
公益社団法人日本薬学会の論文
1977-07-25