Studies with Static Dialysis Method on the Release of Drugs form Nonionic Surfactant Solutions. I. Permeation of Tween 80 through Cellulose Membrane

概要

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A method of determining the small quantities of nonionic surfactants (Tween and Brij types) in the presence of polyethyene glycol was devised utilizing the increase of solubility of yellow AB. With this method, permeation of nonionic surfactants through cellulose membrane was investigated and compared with the results obtained with phosphomolybdic acid method. As the results, it became evident that impurities, especially low molecular weight polyethylene glycol, permeate rapidly, but permeation of nonionic surfactant molecules is negligible. To obtain the magnitude of interaction between benzocaine or sodium salicylate and Tween 80,equilibrium dialysis experiments were successfully carried out employing the cellulose membrane.
公益社団法人日本薬学会の論文
1966-04-25