ガスクロマトグラフィーによる2-(2-furyl)-3-(5-nitro-2-furyl)acrylamideの分析

概要

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A sensitive and specific analysis has been developed for 2-(2-furyl)-3-(5-nitro-3-furyl) acrylamide (Furylfuramide) utilizing gas chromatography (GLC) with hydrogen flame ionization detector (FID) and electron capture detector (ECD). The separation of the trans and cis isomer by direct injection was established using the column paking of 1.5% QF-1 on Anakrom at 200°with nitrogen as carrier gas. In analysis of Furylfuramide these isomers must be identified, and so it seemed that GLC determination was more suitable than chemical methods using spectrophotomeric absorption. Sensitivities obtained were 1γ(FID) and 0.01γ (ECD). Moreover, it was definitetly cleared that cis type of Frylfuramide had two kinds of crystals, α-form (m.p. 160°) and β-form (m.p. 185°), and the transition from α-form to β-form occurred at 160°.
公益社団法人日本薬学会の論文
1967-06-30