透析法による非イオン性界面活性剤溶液からの薬物放出に関する基礎的研究(第4報) : ラット小腸からの薬物吸収におよぼすTween80の影響

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概要

• 論文の詳細を見る

• Theoretical equations of drug absorption from the intestine were derived assuming that permeability characteristic of the intestina1 membrane is not affected by Tween 80 solutions, and that the same mechanism as previously investigated employing a cellulose membrane is applicable. Results of recirculating absorption experiments through rat small intestine in vitro and in situ using benzocaine and sulfisoxazole, thought to be absorbed by passive diffusion, solubilized in the Tween solutions evidenced that these equations are well applicable and the membrane permeability remains unaffected. An equation was derived for the relationship between ratio, r' (total/free drug molecules), in the surfactant solutions and pH of the recirculating solutions, and its applicability was ascertained by means of solubility method and equilibrium dialysis method. In order to investigate kinetically the effect of nonionic surfactants on the rapidity of absorption of drugs at various pH, the latter equation was introduced into the former equations and their applicability was also ascertained using sulfisoxazole with the recirculation method in situ at pH 3.1,4.9,and 7.4. Then, the other equation showing the relationship between amounts of administrated and absorbed drugs from the nonionic surfactant solutions was derived and it applied well to the results of absorption experiments on sulfisoxazole after 30 or 60 minutes' recirculation in situ. Therefore it became possible to anticipate the amount of drugs to be absorbed from the small intestinal tract containing Tween 80 solution.

• 公益社団法人日本薬学会の論文
• 1966-07-25

著者

• 松本 久男

  Faculty Of Pharmaceutical Sciences Fukuoka University:(present Address) Faculty Of Medicine Kurume U

• 松本 久男

  Faculty Of Pharmaceutical Sciences University Of Fukuoka

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• Studies with Static Dialysis Method on the Release of Drugs from Nonionic Surfactant Solution. III. Rapidity of Transfer of Drug Molecules from Micellar to Aqueous Phase
• Studies with Static Dialysis Method on the Release of Drugs from Nonionic Surfactant Solutions. II. Dialysis of Benzocaine Saturated in Tween 80 Solutions
• Studies with Static Dialysis Method on the Release of Drugs form Nonionic Surfactant Solutions. I. Permeation of Tween 80 through Cellulose Membrane
• 透析法による非イオン性界面活性剤溶液からの薬物放出に関する基礎的研究(第4報) : ラット小腸からの薬物吸収におよぼすTween80の影響
• Colorimetric Determination of NO^-_2-N and NO^-_3-N in Water Samples by a Sulfanilamide Diazotation Method after Reduction with Zinc Powder

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